Job Opportunities
- Senior Staff Scientist -- DMPK Biotransformation
- Bioanalytical Senior Research Chemist -- Client/Study Director
- Bioanalytical Senior Research Chemist -- Method Development
- Group Leader -- Discovery Drug Metabolism and Pharmacokinetics
- Group Leader -- Discovery Bioanalytical Research and Biotransformation
Senior Staff Scientist
DMPK Biotransformation
A small molecule, innovator firm in North Carolina is seeking a highly motivated individual with proven ability in determining the biotransformation pathways of small molecules and metabolite identification by LC/MS/MS in drug discovery and early development. This position requires an excellent understanding of drug metabolism, drug metabolizing enzymes (especially cytochrome P450s and conjugating enzymes), and bioanalytical techniques as well as excellent organizational skills and reporting skills. This person will work as a member of our Translational Medicine Group and will be responsible for designing, performing, and interpreting a variety of structural elucidation studies focused primarily on discovery metabolite identification studies in a higher throughput environment. This person will work closely with project teams to guide the team members in drug design with respect to removing metabolic liabilities.
Other responsibilities will include:
- Conducting studies (internal and management of outsourcing where applicable) to select toxicological species and IND enabling studies as new chemical entities progress from discovery to early development
- Mentoring and advising lab associates
- Serving on committees and working teams as the DMPK spokesperson for ADME properties for new chemical entities
- Ensuring and maintaining project schedules and meeting appropriate deadlines, as required
- Attending, participating, and/or leading organized internal/external scientific conferences and forums.
- Composing and preparing manuscripts for publications, scientific papers for internal and external peer-reviewed scientific journals/publications and/or conferences.
- Assisting with the documentation, maintenance, and utilization of SOPs
Requirements
- A Ph.D. in medicinal chemistry or organic chemistry is preferred (pharmaceutical graduate degrees will be considered) plus 5 years of strong experimental metabolism experience in a biotech or pharma industry environment, or a MS with 8 years of experience will be considered.
- For this senior level scientist position, demonstrated experience (at least 5 years) in applying ADME/PK concepts to drug discovery and early drug development is required.
- Hands-on experience with chromatographic separation and small molecule structural elucidation by LC-MS/MS analysis and in vitro ADME assays such as liver microsome and hepatocyte incubations are required.
- The ability to work independently and as part of a team, along with excellent communication skill are essential.
- History of publication and/or presentation in peer-reviewed scientific journals and/or conferences is highly desirable.
- Extensive experience in using modern LC/MS/MS instrumentation from multiple instrument vendors (API 4000/5500 QTrap and Waters/Micromass Q-TOF), especially for drug metabolism applications, will be given strong consideration. A demonstrated knowledge of metabolic pathways and previous experience working with medicinal chemists to guide synthetic strategies is highly desired.
Bioanalytical Senior Research Chemist -- Client/Study Director
A successful CRO has a career opportunity for a Bioanalytical Chemist with proven Method Development/Validation skills using LC/MS/MS. This CRO is a privately owned, mid-sized company doing successful business for over 34 years and has developed a very favorable reputation amongst its clients. Their 80 acre facility is located in Ohio and their employees enjoy a very low cost of living. They have about 550 employees and the average tenure is 8 years. Their internal motto is “Work Hard, Play Hard.” Full relocation benefits will be provided.
Primary Responsibilities
- May serve as study director on analytical studies
- Communicate scientific requirements and results to clients on a regular basis
- Responsibilities include scheduling of study activities, making personnel assignments, inception, review and revision of SOPs to assure compliance with GLPs, auditing of study records for GLP/protocol compliance and the writing of final summary reports
- Duties also include the performance of method development and/or validation for new studies and the orientation and training of new department employees, including maintenance of the associated documentation
- Responsible for development and evaluation of assigned personnel
- Maintains communication of information between the group leader, department coordinator and training specialist concerning the training needs for assigned personnel
- Assures adherence to established safety practices
- Provides technical support to chemists, group supervisors, department management, study directors and clients
- May function as coordinator of a technical specialty area such as instrument and/or software training, or in a non-scientific area such as quality control/efficiency, study scheduling, safety, report preparation, or standard operating procedures
Educational/Technical Requirements
- Ph.D. degree in related field and minimum 7 years experience
- Outstanding verbal and written communicator – must demonstrate proven skills in this area
- Previous Contract Lab experience
- Good Method Development/Validation skills
- Capable of running LC/MS/MS
- Very familiar with GLP requirements
Preferred
- Experience trouble-shooting equipment
- Familiarity with Watson and Sciex equipment
- Experience in a contract lab
Please forward all inquiries to Greg Austin: greg@sentrionllc.com
Bioanalytical Senior Research Chemist -- Method Development
A successful CRO has a career opportunity for a Bioanalytical Chemist with proven Method Development/Validation skills using LC/MS/MS. This CRO is a privately owned, mid-sized company doing successful business for over 34 years and has developed a very favorable reputation amongst its clients. Their 80 acre facility is located in Ohio and their employees enjoy a very low cost of living. They have about 550 employees and the average tenure is 8 years. Their internal motto is “Work Hard, Play Hard.” Full relocation benefits will be provided.
Primary Responsibilities
- Development and validation of new analytical methods including mass spectral methods
- Development of new analytical technology, including associated standard operating procedures
- Training of staff in new methods and technologies
- Responsible for all aspects of analytical support on assigned projects, including interaction with the study director, sponsor monitor, or other representatives of the sponsor, maintenance and review of study records, preparation of reports, and addressing audit findings
- Assists in the direction of daily laboratory operations within the Analytical Chemistry department
- Functions as a senior analyst.
- Review and revision of SOPs to assure compliance with GLPs, auditing of study records for GLP/protocol compliance and the writing of final summary reports.
- May function as coordinator of a technical specialty area such as instrument and/or software training, or in a non-scientific area such as quality control/efficiency, study scheduling, safety, report preparation, or standard operating procedures.
Educational/Technical Requirements
- Ph.D. degree in related field and minimum 7 years experience, M.S. degree and minimum 10 years experience, B.S. degree and minimum 15 years experience or equivalent
- Strong, proven Method Development/Validation skills
- Proven skills in LC/MS/MS
- Very familiar with GLP requirements
Preferred
- Experience trouble-shooting equipment
- Familiarity with Watson and Sciex equipment
- Experience in a contract lab
Please forward all inquiries to Greg Austin: greg@sentrionllc.com
Group Leader -- Discovery Drug Metabolism and Pharmacokinetics
Adventure is Waiting!
Imagine an opportunity to work in a new, world class discovery lab in a booming economy and an exotic land. This is a chance to learn and experience a new culture first hand while doing innovative drug discovery work with a friendly team very eager to learn from you. If you own property in the United States, we will offer an option to keep your property and help you maintain it until your return. It’s truly a chance of a life time!
Bangalore, India
Position Description
The major responsibility of the selected candidate will be to lead the DMPK group, focused on nonclinical pharmacokinetic and metabolism of new chemical entities, in support of various drug discovery programs. He/she will represent the department at all site meetings, and discovery working group meetings, suggest and implement strategies and tactics to address PK/PD/ADME related issues and ultimately enable program decision-making in the selection and advancement of high-quality drug candidates from discovery into development. The incumbent will collaborate with a broad group of scientists in the various discovery departments, as well as scientists across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision, and take a lead in key scientific initiatives.
Position Requirement
- Senior level position with a doctorate in pharmaceutical sciences (e.g. pharmacokinetics, drug metabolism) or a related discipline
- Minimum of 7 years of professional (industry) experience.
- Hands-on experience and in-depth training in the areas of nonclinical pharmacokinetics (PK), pharmacodynamics (PD) and/or drug metabolism are required. These include, but not limited to, PK and PK/PD study design and data analysis, drug metabolism concepts and assays, enzyme kinetics, etc.
- Hands-on experience in conducting in vitro and in vivo studies to assess the ADME of discovery compounds (cell culture, metabolic stability models, CYP inhibition etc.) required.
- Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
- Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix team environment.
- The incumbent should be a strong scientist and be able to manage a group of Ph.D., M.S. and B.S. staff.
Group Leader -- Discovery Bioanalytical Research and Biotransformation
Adventure is Waiting!
Imagine an opportunity to work in a new, world class discovery lab in a booming economy and an exotic land. This is a chance to learn and experience a new culture first hand while doing innovative drug discovery work with a friendly team very eager to learn from you. If you own property in the United States, we will offer an option to keep your property and help you maintain it until your return. It’s truly a chance of a life time!
Bangalore, India
Position Description
The major responsibility of the selected candidate will be to lead the Bioanalytical (BAR) and Biotransformation (BTx) groups. As a leader of the BAR team, the candidate will be responsible for the development, validation, implementation, and troubleshooting of semi-automated multiple component analytical methods for the quantitation of drug candidates in biological matrices. The candidate will be responsible for providing input into the design of experimental protocols and bioanalytical procedures for the analysis of samples and troubleshooting of methods and instruments, and for the evaluation, interpretation, and distribution of bioanalytical results. As a leader of the BTx team, the candidate will focus on exploratory and definitive metabolite identification studies using mass- and radiolabel-based approaches. The candidate should be well-versed with identification of metabolic “soft spots” in new chemical entities and recommend approaches to Medicinal Chemists to modulate metabolic stability. The candidate will represent the department at discovery working group meetings, suggest and implement strategies and tactics to address metabolism and PK-related issues and ultimately enable program decision making in the selection and advancement of high-quality drug candidates into development. The incumbent will collaborate with a broad group of scientists in the various PCO departments, and across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision, and take a lead in key scientific initiatives.
Position Requirement
- Senior level position with a doctorate in Analytical Chemistry or a related discipline
- Minimum of 7 years of professional (industry) experience.
- The candidate should have expert knowledge of Bioanalytical Chemistry, Organic Reaction Mechanisms, Separation and Physical Sciences, Mass Spectrometry, and a good knowledge of ADMET and Pharmacokinetic principles.
- Experience in Bioanalytical quantitation and Metabolite Identification using LC-MS/MS-based methods is required.
- Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
- Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix team environment.
- The incumbent should be a strong scientist and be able to manage a group of Ph.D., M.S. and B.S. staff.
